Moustafa Adel Mohammed Abo Amer
Medical Research Institute Alexandria University
Title: Evaluation of the Expression of ENTPD1/CD39 (Ectonucleoside Triphosphate Diphosphohydrolase-1) and Serum Levels of Vascular Endothelial Growth Factor (VEGF) in Breast Cancer Patients: Correlation with Disease Stage
Biography
Biography: Moustafa Adel Mohammed Abo Amer
Abstract
Breast cancer is a serious life threating condition observed in women, as well as men all over the world and it is highly curable if diagnosed at an early stage .It ranks second, after lung cancer, as a cause of cancer death in women. The incidence of breast cancer is increasing on average by about 1% per year in industrialized countries and at a greater rate in developing countries.
Human tumor cells have evolved numerous strategies to avoid and escape from host mediated antitumor immune response. Among these strategies the accumulation of regulatory T (T-reg) cells at tumor site and in the peripheral circulation has recently attracted significant attention.
The ability of Treg cells to effectively suppress functions of effector T cells responsible for antitumor responses and thus to contribute to tumor progression has been evaluated in patients with different cancers such as, for example breast cancer.
Angiogenesis is known to be an important part of malignant phenotype in most cancers, including breast cancer. Without new vessel formation, tumors cannot grow to more than 2 to 3 mm.
VEGF is a central regulator of angiogenesis and vasculogenesis, because it is a highly specific mitogen for endothelial cells. VEGF binds to VEGF receptors on endothelial cells, triggering endothelial cell proliferation, migration and new vessel formation. The over expression of VEGF may be an early step in a process of metastasis, a step that is involved in the angiogenic switch.
The aim of the current study was to evaluate the expression of CD39 in peripheral blood mononuclear cells (PBMCs) and VEGF serum level of breast cancer patients in correlation with disease stages. This study was conducted on 30 female with breast cancer and 10 normal females as control group.